The most important choice the San Francisco 49ers will make is with the 10 selections they are scheduled to have in the 2025 NFL Draft, including the 11th overall pick.

San Francisco is projected to land four comp picks, and their seventh-round choice via the Panthers came in a trade last year that landed kicker Zane Gonzalez with the 49ers. It’s unclear what the conditions of the pick swap were, so there’s a chance San Francisco actually holds onto its own pick, which is slated for No. 229.

NFL.com's Eric Edholm released his first mock draft of the year, projecting which first-year players each team will select in April. The San Francisco 49ers hold the No.

In Round 1, the 49ers select LSU offensive tackle Will Campbell, who might be the best OT in the class. A glut of talent at other positions allows Campbell to slide all the way to them at the No. 11 overall pick.