Meryl Streep and Emily Blunt were the first cast members confirmed to reprise their roles for the sequel. In June 2025, 20th Century Studios at last confirmed that Anne Hathaway and Stanley Tucci will also return. The company shared a video on Instagram announcing that the sequel is now in production, tagging both Hathaway and Tucci.

Lucy Liu, Simone Ashley, B.J. Novak, Pauline Chalamet, and Justin Theroux join the cast of The Devil Wears Prada 2.

The story reportedly follows Runway’s editor-in-chief, Miranda Priestly, in the twilight of her career, click-clacking against time and the deterioration of traditional magazine publishing.