The Houston Astros wrap up their three-game series against the Giants and a season-opening homestand Wednesday afternoon at Daikin Park looking to avoid a sweep. Framber Valdez will take the mound for his second start of the season.

Wednesday at 4:10 p.m. ET, with the Giants on a three-game winning run.As the favorite, the Giants (-137 moneyline odds) visit

Get San Francisco vs Houston baseball betting preview, spread and over/under insights for their matchup on April 1.

MLB player prop bets and odds for Heliot Ramos on Wednesday, April 2, 2025, as the San Francisco Giants take on the Houston Astros.

Wilmer Flores slugged his fourth home run of the season, Heliot Ramos extended his extra-base hit streak and the visiting San Francisco Giants completed a three-game interleague sweep of the Houston Astros with a 6-3 victory on Wednesday.

Pregame analysis and predictions of the San Francisco Giants vs. Houston Astros MLB game to be played on April 2, 2025 on ESPN.

Wilmer Flores hit his third homer of the season and drove in four runs to lead the San Francisco Giants to a 7-2 win over the Houston Astros.

Logan Webb worked seven strong innings, Heliot Ramos clubbed his third home run, and the visiting San Francisco Giants earned an interleague series victory over the Houston Astros with a 3-1 win on Tuesday.