According to databases such as OMIM, Humsavar, Clinvar and Monarch, 1494 human enzymes are presently associated to 2539 genetic diseases, 75% of which are rare (with an Orphanet code). The Mondo ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Center have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

Deep in our cells, a wide range of processes are occurring constantly. These cellular processes rely on enzymes to act as catalysts and set off a series of molecular interactions. There are still many ...

The transformation of healthy cells into invasive colorectal tumors is an extraordinarily complex process involving numerous molecular mechanisms, according to cancer biologists in China who have ...

Folate coenzymes are pivotal for one-carbon transfers in nucleotide and amino acid metabolism. Microorganisms synthesise folate de novo, making the pathway an attractive target for antimicrobial and ...

Enzyme 'atlas' helps researchers decipher cellular pathways Biologists have mapped out more than 300 protein kinases and their targets, which they hope could yield new leads for cancer drugs ...

A new review maps how the endocrine-microbiome axis expands the estrobolome concept, showing that gut microbes may alter ...

Description Microbial metabolism represents one of the most chemically diverse and functionally complex systems in nature. Despite decades of research, a ...

In a new study published in Science Signaling titled, “Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice,” researchers from ...

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.