Large molecule biotherapeutics are primarily expressed and produced in mammalian host cells then purified from complex mixtures containing growth media and host cell material. Identifying, monitoring, ...

Instead of directly attacking the virus, the compound acts on the host cell and prevents infection.

Parasites are a major global health problem, underlying many human diseases worldwide. For example, Plasmodium falciparum, ...

Host cell protein (HCP) analysis remains a pivotal aspect in the development and manufacture of biopharmaceuticals, ensuring that therapeutic products meet stringent quality and safety standards. HCPs ...

Credit: Molecular Cell (2025). DOI: 10.1016/j.molcel.2025.02.002 Working in collaboration with colleagues at the University of Leiden in the Netherlands, scientists at the University of Cologne's ...

The endoplasmic reticulum (ER) is a crucial organelle present in eukaryotic cells, including human cells. The ER plays a vital part in making sure proteins are properly constructed, and that they get ...

An international team of researchers has identified a promising new approach for treating infections with the Hepatitis E ...

Genes in the nucleus of the host cell have now replaced their functions. Nowack: "These fundamental findings help us understand how an organelle evolves from a bacterium. Using this mechanism, it may ...

Through extracting microbial profiles of lung cancer tissues and combining single-cell analysis, it shows that the distribution of microbiota-related cells and microbiome are related to ...

The production of many therapies based on monoclonal antibodies relies on Chinese Hamster Ovary (CHO) cells. Unfortunately, these cells also make host cell proteins (HCPs), which can make a drug less ...