Lions Beat Saints in Week 1
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The Detroit Lions beat the Indianapolis Colts, 25-16, in their final preseason game of 2026. The Lions' second- and third-stringers faced some starters from the Indianapolis Colts early on in the game Saturday afternoon.
For the 31st straight home game, the Lions will go in as the betting favorite among oddsmakers by a touchdown. According to DraftKings, BetMGM, Caesars and Fanatics odds on Tuesday, the Lions are 7-point favorites, while FanDuel are at a 6.5-point advantage.
NFL Week 1 score predictions, picks, betting odds for Detroit Lions vs New Orleans Saints game Sunday, Sept. 13, 2026. Who will win Week 1 NFL game?