From vaccines to personalized cancer therapies, scientists are studying the use of mRNA across many clinical applications. However, there are several factors that are unique to mRNA drug product ...

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big impact on how well our cells absorb them, paving the way to more efficient ...

Researchers at the Icahn School of Medicine at Mount Sinai say they have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a ...

Lipid nanoparticles address key drug delivery challenges, including immune evasion, toxicity, and regulatory approval.

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...

Small interfering RNA (siRNA) molecules hold immense potential for treating diseases by silencing specific genes. Encapsulated in lipid nanoparticles (LNPs), siRNA can be delivered efficiently to ...

Lipid nanoparticles (LNPs) can deliver their cargoes to the liver, lung and spleen, but targeting them to other organs is more challenging. Reporting in Nature, Lei et al. design LNPs that accumulate ...

Better mRNA release inside cells boosts vaccine and gene editing performance, enabled by redesigned lipid molecules that grip cargo tightly but let go quickly once inside cells. For vaccines, this was ...

Just as a chef perfects a dish by experimenting with flavors and textures, the researchers used an iterative process, testing variations to find the ideal structure for the ionizable lipid. This lipid ...

Malvern Panalytical’s recent peer-reviewed publication, Tailoring Lipid Nanoparticle Dimensions Through Manufacturing Processes, published in RSC Pharmaceutics, features both the NanoSight Pro ...