Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...

Could a Mediterranean diet reduce Alzheimer’s risk for some people more than others? I unpack a new study that shows why those with ApoE4 should (or should not) pay attention to these new ...

Sepsis, a life-threatening condition caused by dysregulated host response to infection, remains a major cause of global ...

Lipid nanoparticles (LNPs) have emerged as a transformative platform in the field of neurotherapeutics, particularly for targeting the aging brain.

A review maps high throughput strategies that link automation, microfluidics, and barcoding into a unified pipeline, enabling faster, more predictive lipid nanoparticle development for genetic ...

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...