The identification of the genes associated with chromosomal translocation breakpoints has fundamentally changed understanding of the molecular basis of hematological malignancies. By contrast, the ...

This patient has macrocytic anemia, occurring in the context of pancytopenia. The most feared cause of macrocytic pancytopenia is aplastic anemia, which is characterized by low counts in all three ...

A high MCV may result from hemolysis, primary vitamin B 12 or folate deficiency, intrinsic factor deficiency, myelodysplasia, or hepatic dysfunction, as occurs in alcoholism. 1,6 Oval macrocytes are ...

THE bone marrow of patients with sickle-cell anemia usually shows normoblastic hyperplasia. In the case reported below, which was complicated by an extracorpuscular hemolytic state, the bone marrow ...

Anemia more often than not may be diagnosed by clinical features alone. A simple blood test is usually enough to confirm the diagnosis of the condition. Diagnostic workup however is needed to ...