EurekAlert!

Matrix stiffness and energy crisis in spinal discs: a new pathway to combat degeneration

Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. In degenerated NP tissue, MRTF-A was activated by increased matrix stiffness and ...
JSTOR Daily

Oxidized low-density lipoprotein alters the effect of matrix stiffness on the formation of endothelial networks and capillary lumens

https://doi.org/10.1086/674309 • https://www.jstor.org/stable/10.1086/674309 Copy URL AbstractFormation of new blood vessels is essential for vascular repair and ...
JSTOR Daily

Polysaccharide hydrogels with tunable stiffness and provasculogenic properties via α-helix to β-sheet switch in secondary structure

Mechanical aspects of the cellular environment can influence cell function, and in this context hydrogels can serve as an instructive matrix. Here we report that physicochemical properties of ...
uni

Dr. Britta Trappmann

Cell fate decisions are influenced by many cues, which together constitute the cell microenvironment. One critical regulator is the extracellular matrix (ECM), which varies not only in composition, ...
BioTechniques

Computational modeling takes the guesswork out of developing injectable hydrogels

Researchers have developed a computational framework to predict the properties of granular hydrogel matrices. A granular hydrogel matrix could be transformative in several biomedical applications ...