The immune system regulates homeostasis by attacking foreign bacteria, viruses, and other infections. Different immune cells are generated for specific functions to fight off disease and to maintain ...

This news release is available in German. Clay can be used in various forms for a range of objects such as cups, plates or bricks. Similarly, proteins can transform their structure and thus adapt ...

Transcription factors are genes that, once expressed, can influence the activity of other genes, sometimes many other genes. There are hundreds of transcription factors in human cells that we know of, ...

Modulation of a single amino acid in the reprogramming factor Kruppel-like factor 4 (KLF4) has been demonstrated to markedly improve natural transcription factor function and to result in faster and ...

Researchers have been on an ongoing quest to target transcription factors (TFs), a notoriously hard-to-block class of proteins that, when mutated or dysregulated, can disrupt cell function and drive ...

Sequence-specific, DNA-binding TFs are the major regulators of cell identity and cell physiology. As examples, expression of select TFs can revert differentiated cells back to a pluripotent state and ...

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, according to a recent study published in ...

Banner image: Human cancer cells seen under the microscope. (Credit: National Cancer Institute) CU Boulder researchers have discovered a new way to inhibit the most commonly mutated gene underlying ...

Scientists at St. Jude Children's Research Hospital have reconciled two closely related but contentious mechanisms underlying transcription, the process of converting genetic information in DNA into ...