The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

Bloodstream forms of Trypanosoma brucei lack cytochromes and are, therefore, insensitive to cyanide. Azide is a toxic anion that bears chemical and biological properties in common with cyanide and may ...

Bloodstream forms of Trypanosoma brucei brucei were grown over baby hamster kidney cells in minimum essential medium with various concentrations of metronidazole (Flagyl) and chloroquine. Both drugs ...

Trypanosoma are a nasty class of single-celled parasites that cause serious, even fatal, diseases in human and animals. Two species cause sleeping sickness, a disease that threatens all of ...

African sleeping sickness, caused by the parasite Trypanosoma brucei, is transmitted by the tsetse fly and is fatal if left untreated. New research reveals a method to manipulate trypanosomes in the ...

If left untreated, African Sleeping Sickness can causes meningoencephalitis, coma, and death. The disease is spread through tsetse flies that feed on infected hosts. In 2015, 84 percent of Trypanosoma ...

Trypanosoma brucei infection induces fat breakdown, but this strategy benefits the host. To uncover how the parasite induces fat loss, the researchers used wildtype and knockout mice that lacked ...

Trypanosoma brucei infection disrupts the sleep-wake cycle, leading to daytime sleepiness and insomnia at night. Scientists now know how the parasites do this. “We were curious to know if the parasite ...

Researchers at the Salk Institute for Biological Studies have shown a possible beneficial role for muscle wasting in mice infected with Trypanosoma brucei, a parasite that causes sleeping sickness in ...