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Endocrine Therapy Resistance in HR+/HER2- Breast Cancer: A Common Clinical Challenge
Endocrine therapy typically slows cell cycle progression by reducing cyclin D1, which partners with CDK4/6 to promote cell ...
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Oral drug combination extends progression-free survival in advanced ER-positive breast cancer
Patients with estrogen-receptor-positive HER-2-negative advanced breast cancer showed significantly improved progression-free ...
In the phase 1 portion of the trial, two doses of gedatolisib were administered IV on an intermittent schedule (Days 1, 8, 15 ...
MedPage Today on MSN
For Your Patients: Next Steps If There Is Resistance to Endocrine Therapy
When cancer progresses on endocrine therapy, the next step is likely either a biopsy to gather tissue for testing or a liquid ...
Patients who progressed on first- or second-line therapy were the population evaluated in the CABINET trial (NCT03375320). Anthony suggests that patients with pancreatic and pulmonary NETs, ...
(A) The Venn diagram showed the distribution of the DEGs between circFKBP8(5S,6) and cFKBP8-regulated genes. (B, C) DEGs involved in the neuroactive ligand-receptor ...
In a recent study published in Molecular Psychiatry, researchers review the anti-inflammatory effects of ketamine in the peripheral and central nervous systems. To this end, all relevant articles were ...
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