The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

Existing metabolic models of Trypanosoma brucei have aided in the search for new drug targets in this parasite but provide only a limited picture of cellular metabolism. Kerkhoven et al. now expand ...

This is a preview. Log in through your library . Abstract In almost all eukaryotes, mitochondria maintain their own genome. Despite the discovery more than 50 y ago, still very little is known about ...

Bloodstream forms of Trypanosoma brucei lack cytochromes and are, therefore, insensitive to cyanide. Azide is a toxic anion that bears chemical and biological properties in common with cyanide and may ...

Researchers found an unexpected diversity of protein coats within populations of <i>Trypanosoma brucei</i>, challenging the conventional understanding of the dynamics that allow the parasite to ...

African sleeping sickness, caused by the parasite Trypanosoma brucei, is transmitted by the tsetse fly and is fatal if left untreated. New research reveals a method to manipulate trypanosomes in the ...

Trypanosoma brucei infection induces fat breakdown, but this strategy benefits the host. To uncover how the parasite induces fat loss, the researchers used wildtype and knockout mice that lacked ...

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health sheds light on how the blood-borne parasite that causes African sleeping sickness in humans and related diseases ...

Trypanosoma brucei infection disrupts the sleep-wake cycle, leading to daytime sleepiness and insomnia at night. Scientists now know how the parasites do this. “We were curious to know if the parasite ...

If left untreated, African Sleeping Sickness can causes meningoencephalitis, coma, and death. The disease is spread through tsetse flies that feed on infected hosts. In 2015, 84 percent of Trypanosoma ...

Researchers at the Salk Institute for Biological Studies have shown a possible beneficial role for muscle wasting in mice infected with Trypanosoma brucei, a parasite that causes sleeping sickness in ...