A team of researchers at the University of California, Davis, made small tweaks to the molecular structure of lysergic acid diethylamide (LSD) to see if it could be turned into an effective brain ...

Specifically, they made a tiny adjustment—flipping the position of just two atoms in LSD’s molecular structure. This new version, JRT, ...

JRT has the same molecular weight and general shape as LSD. But that small atomic switch made it behave very differently. It became highly selective for the 5-HT2A receptor—the key site for ...

The researchers managed to do this by altering the position of just two atoms in LSD’s molecular structure. This small shift produced major changes, and the researchers have begun calling the ...

To design the drug, dubbed JRT, researchers flipped the position of just two atoms in LSD’s molecular structure. The chemical flip reduced JRT’s hallucinogenic potential while maintaining its ...

UC Davis researchers have developed a new, neuroplasticity-promoting drug closely related to LSD that harnesses the psychedelic’s therapeutic power with reduced hallucinogenic potential.

To design the drug, dubbed JRT, researchers flipped the position of just two atoms in LSD's molecular structure. The chemical flip reduced JRT's hallucinogenic potential while maintaining its ...

The researchers focused on the chemical structure of LSD itself. Prior studies have suggested that certain parts of the LSD molecule are responsible for triggering hallucinations – specifically, a ...

The LSD molecule is extremely complex, and researchers are still unsure which aspect of its structure creates the antidepressant effect, and which causes the hallucinations.

They used that structure to model the 5HT2a until Roth’s group worked out the crystal structure of 5HT2a. The compounds had been selected from a computational library of 75 million candidates.

A team of researchers at the University of California, Davis, made small tweaks to the molecular structure of lysergic acid diethylamide (LSD) to see if it could be turned into an effective brain ...

To design the drug, dubbed JRT, researchers flipped the position of just two atoms in LSD’s molecular structure. The chemical flip reduced JRT’s hallucinogenic potential while maintaining its ...