The Longevity India Conference 2025 - Rise for Healthy Aging, hosted at the Indian Institute of Science (IISc), concluded its final day with impactful discussions on longevity science. The discussions ...

Circular RNA (circRNA) is a subclass of non-coding RNAs that enables the circular transcripts resistant to the exonuclease digestion. Iron homeostasis is essential for the body to maintain normal ...

State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, 2 Southeast University Road, Nanjing 211189, China ...

Obesity is one of the more prevalent diseases, which results in energy imbalance within metabolic tissues and lysosome dysfunction. Less frequent diseases include Niemann-Pick type C (NPC) and Gaucher ...

Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...

U.S., and colleagues have designed and constructed a lysosome-targeted photoinduced pyroptosis and ferroptosis theranostic nanoplatform M@P by self-assembly of photosensitizer MTCN-3 and ...

The title should instead appear as “Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy.” The legends for Figs. 1, 5, and 6 appeared ...

Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...

These mechanisms may serve as a checkpoint for the presence of the vacuole/lysosome. Animals, fungi and other eukaryotes have cells that are divided into sub-compartments that are called organelles.