BMJ12d
Diagnosis of osteoporosis in statin-treated patients is dose-dependent
Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this study was set out to ...
BMJ11d
mTOR inhibition by metformin impacts monosodium urate crystal–induced inflammation and cell death in gout: a prelude to a new add-on therapy?
Objective Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases. The inflammation is caused by the deposition of ...
BMJ3d
Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren’s syndrome
2 Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China Correspondence to Hua Chen, Department of Rheumatology and Clinical Immunology, Peking Union Medical ...
BMJ3d
POS0095 CaMK4 CONTROLS T REGULATORY CELL METABOLISM AND DEFINES THEIR FUNCTION AND STABILITY IN SYSTEMIC LUPUS ERYTHEMATOSUS
Background Calcium/Calmodulin-dependent protein kinase IV (CaMK4) is a serine kinase expressed in CD4 T cells whom activity is increased in patients with active systemic lupus erythematosus (SLE). We ...
BMJ11d
Barbara Ansell: a person ahead of her time
In 1951, Barbara Ansell, a young 28-year-old physician and aspiring cardiologist, was encouraged by Professor Eric Bywaters to join him in the Special Unit for Juvenile Rheumatism, recently created by ...
BMJ9d
Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study
5 The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Objectives and methods With 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were ...
BMJ6d
The cervical spine in patients with psoriatic arthritis
Objective: To establish the incidence of clinically important inflammatory cervical spine abnormalities in radiographs of patients with psoriatic arthritis (PsA). Methods: Patients were selected from ...
BMJ5d
AB0536 EFFECT OF HYDROXYCHLOROQUINE TREATMENT IN MUCOCUTANEOUS MANIFESTATIONS IN PATIENTS WITH BEHÇET’S SYNDROME
Background: Behçet syndrome (BS) is a rare multisystemic vasculitis, most commonly seen in regions along the ancient Silk Road. It runs a relapsing and remitting course. Mucocutaneous disease, ...
BMJ9d
Factors associated with long-term cardiac dysfunction in neonatal lupus
Objectives Cardiac manifestations of neonatal lupus (NL) have been associated with significant morbidity and mortality; however, there is minimal information on long-term outcomes of affected ...
BMJ5d
SAT0105 Losartan but not irbesartan reduces serum uric acid in hypertensive patients with gout
Background Losartan is the only angiotensin II receptor antagonist with uricosuric properties and has been shown to decrease serum uric acid (SUA) levels in normal subjects as well as in hypertensive ...
BMJ13d
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis
1 Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands 2 Department of Rheumatology, Leiden University Medical Centre, Leiden, ...
BMJ9d
Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis
Objectives To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular ...