BMJ11d
Global, regional and national burden of rheumatoid arthritis 1990–2017: a systematic analysis of the Global Burden of Disease study 2017
Objectives To provide the level and trends of prevalence, incidence and disability adjusted life years (DALYs) for rheumatoid arthritis (RA) in 195 countries from 1990 to 2017 by age, sex, ...
BMJ8d
Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis
Objectives In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine ...
BMJ12d
Diagnosis of osteoporosis in statin-treated patients is dose-dependent
Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this study was set out to ...
BMJ11d
Contrasting contributions of TNF from distinct cellular sources in arthritis
2 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology RAS, Moscow, Russian Federation Objectives Neutralisation of tumour necrosis ...
BMJ12d
Single-cell RNA-seq analysis reveals the progression of human osteoarthritis
2 Biomedical Institute for Pioneering Investigation via Convergence and Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China 3 Beijing Advanced Innovation ...
BMJ7d
Risk of venous thromboembolism in knee, hip and hand osteoarthritis: a general population-based cohort study
4 Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China 5 National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, ...
BMJ12d
Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression
1 University of Leeds Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK Background The human enthesis conventional T cells are poorly characterised. Objectives To study the biology ...
BMJ11d
mTOR inhibition by metformin impacts monosodium urate crystal–induced inflammation and cell death in gout: a prelude to a new add-on therapy?
Objective Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases. The inflammation is caused by the deposition of ...
BMJ3d
Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren’s syndrome
2 Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China Correspondence to Hua Chen, Department of Rheumatology and Clinical Immunology, Peking Union Medical ...
BMJ3d
POS0095 CaMK4 CONTROLS T REGULATORY CELL METABOLISM AND DEFINES THEIR FUNCTION AND STABILITY IN SYSTEMIC LUPUS ERYTHEMATOSUS
Background Calcium/Calmodulin-dependent protein kinase IV (CaMK4) is a serine kinase expressed in CD4 T cells whom activity is increased in patients with active systemic lupus erythematosus (SLE). We ...
BMJ12d
Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
2 Tianjin Clinical Research Center for Rheumatic and Immune Diseases, Tianjin, China Correspondence to Dr Wei Wei, Department of Rheumatology and Immunology, Tianjin Medical University General ...
BMJ10d
Initial glucocorticoid bridging in rheumatoid arthritis: does it affect glucocorticoid use over time?
Objectives To compare the use of glucocorticoids (GC) over time in patients with rheumatoid arthritis (RA) who were or were not treated initially with GC bridging therapy. Methods Data from the BeSt, ...