Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...

Massage might help your brain flow regain its mojo. On June 4 in Nature, researchers led by Gou Young Koh at the Institute for Basic Science in Daejeon, South Korea, mapped the labyrinth of lymphatics ...

Since February, the termination of some 2,482 grants worth $8.6 billion has shaken the scientific community, including AD researchers. Thanks to government databases and intrepid scientists tracking ...

To test for links between viral immune response and dementia, the researchers focused on a subgroup of 91 people with dementia and 98 healthy controls who tested negative for amyloid. They found that ...

In a healthy brain, border-associated macrophages within the dura mater and choroid plexus are replaced by circulating monocytes, while those in the leptomeninges and perivascular spaces, and also ...

T cells have been found in the brain meninges as well (May 2021 news; Feb 2025 news), but flow cytometry and single-cell RNA sequencing confirmed that these SFO CD4+ T cells are distinct. They ...

To report consequences on AD research, Alzforum has spoken with scientists across the board, including some whose research has been subject to funding cuts, as well as some who have so far remained ...

Other Phenotypes Premature death, attributed to hindbrain tauopathy, generally occurs between eight and 12 months (Dutschmann et al., 2010). Premature death is preceded by weight loss, hyperkyphosis, ...

Due Date Letter of Intent due September 16, 2025. Application due October 17, 2025. View Grant ...

Award Application budgets are not limited but must be commensurate with the scope of the proposed research. The maximum project period is five years.